Zhang X dataset is the quantification and measurement of TRPM8 firing, currents and fluorescence signals under different conditions. The data were collected with electrophysiological recordings and confocal imaging of single cells. TRPM8-Gq modelling is the proposed structural interaction between TRPM8 and Galpha q using the Discovery studio 4.0 software. The data were collected for elucidating the mechanisms of TRPM8 modulation and gating.