Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients

Ademowo, Stella and Dias, Irundika and Milic, Ivana and Devitt, Andrew and Moran, Rachel and Mulcahy, Riona and Howard, Alan and Nolan, John and Griffiths, Helen (2017) Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients. [Data Collection]

Collection Method

Data was obtained from Alzheimer’s disease (AD) patients (attending the Age-Related Care Unit at Waterford University Hospital Ireland and healthy control subjects with the same age) prior to the administration of carotenoid (antioxidant) supplements and six months after commencement of supplementation. Mild to moderate AD was defined as an average Mini-Mental State Examination (MMSE) score of 14-24, with some alteration in behaviour as well as difficulties in carrying out day-to-day tasks. Cognitive function was assessed with different cognition tests which includes a semantic fluency score using ‘Animal’ category (as many examples in one minute), and a phonemic fluency score using the ‘FAS’ test (as many words starting with letters F, A and S, one minute per letter) The novel oxidised phospholipid biomarker 1-palmitoyl-2-(5'-oxo-valeroyl)-sn-glycero-3-phosphocholine (POVPC) was analysed using electrospray ionization tandem mass spectrometry (MS) with multiple reaction monitoring (MRM), 8-isoprostane (IsoP) was measured by ELISA and ferric reducing antioxidant potential (FRAP) was measured by a colorimetric assay. All statistical analyses were performed using Prism statistical analysis software package (Version 7).


Type of Data: Dataset
Divisions: Life and Health Sciences > Cell and Tissue Biomedical Research
Data Publisher: Aston University
Funders: Biotechnology and Biological Sciences Research Council, Kidney Research Foundation, ARUK, The Howard Foundation, Aston Research Centre for Healthy Ageing
Keywords: oxidative stress, lipid peroxidation, POVPC, mass spectrometry, lutein, eso-zeaxanthin, zeaxanthin, cognitive function, supplementation
Geographic coverage: Birmingham, United Kingdom
Statement on legal, ethical and access issues: There are no legal, ethical or access issues regarding this dataset
Date Made Available: 16 March 2017
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FRBM 2017 data.xls
Available under License Creative Commons Attribution.

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