Fixed Dose Combination Orally Disintegrating Tablets to Treat Cardiovascular Disease: Formulation, in vitro Characterization and Physiologically Based Pharmacokinetic Modelling to Assess Bioavailability

Dennision, Thomas and Smith, Julian and Badhan, Raj and Mohammed, Afzal (2017) Fixed Dose Combination Orally Disintegrating Tablets to Treat Cardiovascular Disease: Formulation, in vitro Characterization and Physiologically Based Pharmacokinetic Modelling to Assess Bioavailability. [Data Collection]

Collection Method

The Excel files contain dissolution data for both single and FDC formulations, which have been corrected for samples withdrawn under sink conditions. Data is also included for Caco-2 drug permeability studies and show the mass transfer of drug from both A-B and B-A directions over the study period

Metadata

Type of Data: Dataset
Divisions: Life and Health Sciences > Applied Health Research Group
Data Publisher: Aston University
Funders: Medical Research Council
Grant number: MR/J01236X/1
Corporate Creators: Viridian Pharma Ltd
Keywords: Orally disintegrating tablet, Fixed dose combination, Cardiovascular disease, Physiologically based pharmacokinetic modelling, Bioavailability, Bioequivalence
Geographic coverage: Birmingham, United Kingdom
Statement on legal, ethical and access issues: There are no legal, ethical or access issues regarding this dataset.
Date Made Available: 3 February 2017
Collection period:
FromTo
May 2016September 2016
Identification Number: 10.17036/researchdata.aston.ac.uk.00000178
Publication URL: http://publications.aston.ac.uk/29932/

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amlod and atorv permeability.xlsx
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Amlodipine Fasted Combined Summary.xlsx
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Amlodipine Fasted Single Summary.xlsx
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Amlodipine fed Combined Summary.xlsx
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Amlodipine Fed Single Summary.xlsx
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Atorvastatin Fasted Combined Summary.xlsx
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Atorvastatin Fasted Single SUMMARY.xlsx
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Atorvastatin Fed Combined.xlsx
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Atorvastatin Fed Single.xlsx
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Dissolution .xlsx
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HPLC Dissolutions for Raj.xlsx
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